This sensitivity analysis was the same as the main analysis in

Patients who had events in the first 90 days were censored from further follow up and could not serve as controls at a later time, as was the case with any patient who had an event. This sensitivity analysis was the same as the main analysis in all other respects.Meta analysis of site specific resultsThe data analysts at each site were kept blind to the results of other sites until after the meta analysis was completed. For the meta analysis, we pooled the results from each site using fixed effects and random effects models.

pandora jewelry We used these patient specific net monetary benefits to derive cost effectiveness acceptability curves and estimated the aggregate benefit from the equation:where is the decision maker’s maximum willingness to pay for a QALY. For example, if treatment A has a mean cost of 100000 and generates a mean of five QALYs with a QALY valued at 30000, then the net monetary benefit associated with treatment A is 50000 ((530000)100000).Thus the net monetary benefit depends on the value of the QALY, and analysis shows how sensitive the results are to changes in this value. The uncertainty around the net monetary benefit can estimate the probability that a strategy is cost effective through the cost effectiveness acceptability curve. pandora jewelry

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